Technology

Motivations

Lack of effective diagnostics is a leading cause of millions of lives lost to infectious diseases each year. Countless patients around the world also contract secondary infections from blood transfusion and other clinical contacts due to insufficient screening for the surging drug-resistant bacterial or viral pathogens. There is now an urgent need for portable, precise and globally affordable diagnostics solutions that would allow rapid response.

In spite of past innovations in technologies such as microfluidics to help with miniaturization, truly portable molecular diagnostics systems have largely eluded us due to lack of compact opto-electronic instrumentation.

We strive to solve this problem by creating a class of ultra low-light CMOS biosensors such as the ULS24. Anitoa's ULS24 is highly sensitive and integrated, yet costs less to use. It can replace the bulky and expensive PMTs and CCDs in today's molecular testing instruments.

Applications of Anitoa Ultra low-light CMOS Biosensor

DNA and RNA quantification, fluorescent-based
Miniaturized qPCR, microfluidic qPCR, and digital PCR
Fluorescence or chemiluminescence-based Immunoassay/ELISA
DNA or Protein microarray
Pyro-sequencing
Capillary electrophoresis
Cell sorting/Imaging flow cytometry
Fluorescence Images Guided Surgery (FIGS)

Anitoa ULS24 is world's most sensitive CMOS bio-optical sensor, capable of low-light sensitivity of 3E-6 lux.

Anitoa ULS24 CMOS bio-optical sensor works with microfluidic chip to test onchip DNA hybridization (in colaboration with Micronit BV).

A portable chemiluminescence immunoassay (CLIA) test instrument for in-home monitoring of cell-pathogen interaction in patients, using Anitoa's ULS24 CMOS bio-optical sensor (in colaboration with Lucentix SA).

Anitoa ULS24 CMOS bio-optical sensor applied in qPCR to achieve portability and calibration-free operation.

Application Notes - Maverick qPCR Systems

Product Brochure: Maverick qPCR Systems

Application Note: Achieving Fast Amplification with Maverick qPCR Systems

Application Notes - CMOS Biosensor

Download a White paper on Anitoa's CMOS biosensor innovation

Shortened Version Full Version

Application Note: How to integrate ULS24 in an embedded system.

Application Note: Different options of adding optics to ULS24.

Application Note: How to perform temperature compensated dark subtraction in ULVision.

Application Note: How to automatically calibrate ULS24 integration time.

Application Note: Quantum dot applications in fluorescence imaging – calibration and molecular imaging.

Application note on DNA quantification with Anitoa's CMOS-based fluorescence imager.

Application Note: Using ULS24 for Chemiluminescence Immunoassay and DNA Hybridization.