We develop effective diagnostics technology aimed at fighting infectious diseases around the world
Motivations
Lack of effective diagnostics is a leading cause of millions of lives lost to infectious diseases each year. Countless patients around the world also contract secondary infections from blood transfusion and other clinical contacts due to insufficient screening for the surging drug-resistant bacterial or viral pathogens. There is now an urgent need for portable, precise and globally affordable diagnostics solutions that would allow rapid response.
Technology
In spite of past innovations in technologies such as microfluidics to help with miniaturization, truly portable molecular diagnostics systems have largely eluded us due to lack of compact opto-electronic instrumentation.
We strive to solve this problem by introducing ultra low-light CMOS biosensors (e.g. Anitoa ULS24) that are highly sensitive and integrated, yet low cost to replace the bulky and expensive PMTs and CCDs in today's molecular testing instruments, to achieve portability.
Applications of Anitoa Ultra low-light CMOS Biosensor
DNA and RNA quantification, fluorescent-based
Miniaturized qPCR, microfluidic qPCR, and digital PCR
Fluorescence or chemiluminescence-based Immunoassay/ELISA
DNA or Protein microarray
Pyro-sequencing
Capillary electrophoresis
Cell sorting/Imaging flow cytometry
Fluorescence Images Guided Surgery (FIGS)
Anitoa ULS24 CMOS bio-optical sensor works with microfluidic chip to test onchip DNA hybridization (in colaboration with Micronit BV). A portable chemiluminescence immunoassay (CLIA) test instrument for in-home monitoring of cell-pathogen interaction in patients, using Anitoa's ULS24 CMOS bio-optical sensor (in colaboration with Lucentix SA).Anitoa ULS24 CMOS bio-optical sensor applied in qPCR to successfully detect E Coli. (DH5a), HBV (wild type and rtM2041), HPV (type 16, 18), foot-and-mouth disease (EV71 and CA16), African Swine Flu (ASF) virus and the 2019 New Coronavirus (2019-nCoV).
